What is a common clinical feature of Sjögren's syndrome?

A common clinical feature of Sjögren's syndrome is the presence of dry mouth (xerostomia) and dry eyes (xerophthalmia). This autoimmune disorder primarily affects the exocrine glands, leading to a reduction in secretions that normally keep the mouth and eyes moist. The pathophysiology involves lymphocytic infiltration in these glands, resulting in inflammation and dysfunction.

Patients with Sjögren's syndrome often report difficulties with swallowing due to dry mouth, and may experience discomfort, redness, or a gritty feeling in the eyes due to insufficient tear production. These symptoms are hallmark indicators of the condition and help differentiate it from other disorders that may present with fatigue, rash, or other systemic symptoms.