What treatment is first-line for children with uncomplicated otitis media?

Amoxicillin is the first-line treatment for children with uncomplicated otitis media due to its effectiveness against the most common pathogens responsible for this condition, particularly Streptococcus pneumoniae and Haemophilus influenzae. It is well-tolerated by children, has a favorable safety profile, and is cost-effective, making it a preferred choice in pediatric care.

In uncomplicated cases, the use of amoxicillin is supported by clinical practice guidelines, which promote its use as the initial antibiotic therapy. If a child has a documented allergy to penicillin, alternative antibiotics may be considered; however, for those who can tolerate it, amoxicillin remains the standard due to its efficacy and narrow spectrum that minimizes the risk of promoting antibiotic resistance. This choice helps ensure that treatment is both effective in resolving the infection and prudent in terms of public health considerations.