Which class of antibiotics can potentially cause cartilage damage and should be avoided in pregnancy?

Fluoroquinolones are a class of antibiotics that are associated with the potential risk of causing cartilage damage, particularly in developing joints of fetuses and young children. This risk has been demonstrated in animal studies, where exposure to fluoroquinolones led to issues such as arthropathy. As a result of these findings, the use of fluoroquinolones during pregnancy is generally contraindicated due to the potential harm to fetal development.

Fluoroquinolones work by inhibiting bacterial DNA gyrase and topoisomerase IV, which are essential for bacterial replication and survival. The structural integrity and function of cartilage can be adversely affected by these agents, making it crucial for pregnant individuals to avoid their use to prevent any potential long-term impacts on the musculoskeletal system of the developing fetus.

In summary, fluoroquinolones are the correct choice as they carry specific risks related to cartilage damage during pregnancy, warrants careful consideration in prescribing practices to protect maternal and fetal health.